I haven't used Blender extensively or anything, but I figure it has the same issue as most big open source programs: The GUI changes often (due to more cooks in the kitchen), the GUI is overly complex and its stability leaves a lot to be desired. Zbrush has its fair share of crashes too though, especially if you don't disable windows defender before you install it.
ZBrush wont animate things for you. So if that's your end goal you may need blender anyway since 3d software like maya can be over 2000 USD. ZBrush has a free trial, so maybe give it a whirl and see what you think either way.